My research agenda addresses quantitative problems in evolutionary and developmental biology by using a combination of computational, mathematical and experimental tools. Starting with biologically relevant models, we comb for data from existing studies, and in close collaboration with experimentalists, we generate new data. In turn, this data allows us to refine the models, thus guiding both experimental and modeling processes. The ability to test models in this way is facilitated by data generated from systematic genomics efforts undertaken in recent years. Central to my approach is an evolutionary perspective in examining the hypotheses arising from the combination of theoretical model and biological data.